Endocrine Abstracts

Fasting produces a rapid reduction of the activity of the central arm of the hypothalamic–pituitary–thyroid (HPT) axis, with a drop in biosynthesis of thyrotropin releasing hormone (TRH) in periventricular and medial parvocellular neurons of the paraventricular nucleus (PVN), and decreased TRH release into the pituitary portal capillaries. These events contribute to fasting-induced suppression of serum thyroid hormone levels, an adaptive mechanism to conserve energy....

Angiotensin II (A-II) stimulates aldosterone (aldo) secretion through the zona glomerulosa AT1R. A-II can be metabolized to angiotensin III (A-III) which also stimulates aldo synthesis. In the rat A-III stimulates aldo secretion through the AT2R receptor.The human adrenocortical HAC15 cells were incubated with A-II or A-III (10 nM) for 24 h and the concentration of aldo and cortisol (F) measured in the media. A-II produced a fourfold and A-III a twofold ...

Diagnosis of primary aldosteronism (PA) is made by screening, confirmation testing and subtype diagnosis (CT scan and adrenal vein sampling, AVS). However, some tests are costly and unavailable in most hospitals. We evaluated the role of serum 18-hydroxycorticosterone (s18OHB) and urinary and serum 18-hydroxycortisol (u and s18OHF) and 18-oxocortisol (u and s18oxoF) in the diagnosis of PA and its subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (...